Removing Barriers That Prevent Parents From Low Socioeconomic Backgrounds From Being Involved in Their Children’s High School Education

Abstract The purpose of this qualitative case study was to describe the barriers that prevent parents from low socioeconomic backgrounds from being involved in their children’s high school education at District X in rural East Texas. Fifteen high school teacher participants were interviewed and provided their experiences and perceptions to support the interviews and focus groups. The primary findings identified teachers’ perceptions of the barriers that prevent parental involvement, parents’ commitment to their children’s high school education, and the teacher’s role in removing barriers that prevent parents from low socioeconomic backgrounds from being involved in their children’s high school education. Building solid partnerships, attending cultural and parental involvement training, creating shared commitments with parents, and developing positive perceptions of parents were strategies teachers used to help remove barriers that prevented parents from low socioeconomic backgrounds from being involved in their children’s high school education. Increasing two-way communication with parents, being culturally sensitive, and improving COVID-19 safety measures created a welcoming environment for parents. School districts must improve professional development practices throughout the school year to increase parental involvement through creative strategies and programs. This study is important because of the decrease in parental involvement for parents from low socioeconomic backgrounds, and it provides pertinent information for parents and teachers to create a sustainable partnership

Memory, plasticity and sleep - A role for calcium permeable AMPA receptors?

Experience shapes and molds the brain throughout life.These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter release or through neurotransmitter detection at synapses. The predominant neurotransmitter receptor in excitatory transmission, the AMPA-type glutamate receptor (AMPAR), is exquisitely sensitive to changes in experience and synaptic activity. These ion channels are usually impermeable to calcium, a property conferred by the GluA2 subunit. However, GluA2-lacking AMPARs are permeable to calcium and have recently been shown to play a unique role in synaptic function. In this review, I will describe new findings on the role of calcium permeable AMPARs (CP-AMPARs) in experience-dependent and synaptic plasticity.These studies suggest that CP-AMPARs play a prominent role in maintaining circuits in a labile state where further plasticity can occur, thus promoting metaplasticity. Moreover, the abnormal expression of CP-AMPARs has been implicated in drug addiction and memory disorders and thus may be a novel therapeutic target

Prospectus, April 3, 2008

https://spark.parkland.edu/prospectus_2008/1008/thumbnail.jp

Prospectus, January 24, 2008

https://spark.parkland.edu/prospectus_2008/1000/thumbnail.jp

Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662

Metformin (Met) is a biguanide drug widely used in the treatment and management of non insulin-dependent diabetes mellitus. In recent years it has emerged that Met, by stimulating adenosine monophosphate-activated protein kinase (AMPK), can promote the maturation of osteoblasts, albeit cells sourced from rodent and murine calvaria. Finding novel uses for existing drugs is especially appealing, primarily from the fiscal and time constraints posed in developing new products. Identifying agents capable of supporting human osteoblast growth and differentiation are attractive in a bone regenerative context. Since studies using Met are invariably restricted to rodent and murine osteoblasts we sought to investigate whether this biguanide might have a positive influence upon human osteoblast growth and maturation. To this end we examined the effect of Met on two osteoblast-like cell lines, MG63 and Saos-2, and compared the responses to primary human osteoblasts and their bone marrow-derived stem cell progeny. Furthermore we examined the effect of a cell permeable Met surrogate, A769662, which is a potent and far more selective activator of AMPK. Herein we report that Met is without influence on cell growth. Furthermore the application of Met, albeit in the millimolar range, actually inhibited osteoblast maturation. Conversely A769662 was toxic to the osteosarcoma-derived cell lines, MG63 and Saos-2, but without effect on the growth of primary cells or their stem cell progenitors. Since the cell lines are known to be p53 deficient we propose that activation of AMPK by A769662 could form part of the arsenal in the fight against osteosarcoma

Prospectus, February 7, 2008

https://spark.parkland.edu/prospectus_2008/1002/thumbnail.jp